Synthesis of a nitrogen analogue of salacinol and its alpha-glucosidase inhibitory activity.
نویسندگان
چکیده
A nitrogen analogue 4 of the naturally occurring sulfonium ion salacinol (1), a potent alpha-glucosidase inhibitor isolated from the Ayruvedic medicine Salacia reticulata, was synthesized and its inhibitory activity against alpha-glucosidase tested. Substitution of the sulfur atom in 1 with a nitrogen reduced the activity considerably. The solid-state stereostructure of the related compound (5) was determined on the basis of single crystal X-ray measurement.
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ورودعنوان ژورنال:
- Chemical & pharmaceutical bulletin
دوره 49 11 شماره
صفحات -
تاریخ انتشار 2001